Medicine is an ever．changing SCience．As new research and clinical experience broaden our knowledge．changes in treatment and drug therapy ale required．The auors and the publisher of this work have checked with sources believed to be reliable in their efforts to provide info mation that is complete and generally in accord wim the standards accepted at the time of publi— cation．However，in view of the possibility of human error or changes in medical sciences，nei- ther the authors nor the Publisher nor any 0tIler party who has been involved in the preparation or publication Of tlis work warrants that the information contained herein is in every respect ac- curate or complete。and they disclaim all responsibility for any errors or omissions or for the re- suits obtained from use of the information contained in this work．Readers are encouraged to confirlTl the information contained herein with other sources．For example and in particular， readers are advised to check product information sheet included in the package of each drug mev plan to administer tO be certain that the information contained in this WOrk iS accurate and tlat changes have not been made in the recommended dose or in the contraindications for ad— IIlinistration．TS recommendation is of particular importance in connection with new or infre- quentiy used drugs．