阿瑟·科恩伯格(Arthur Kornberg),美國生物化學傢,1918年3月12日生於紐約。1941年他獲得博士學位,1953年任華盛頓大學教授。科恩伯格主要的成就是酶化學。他成功地從大腸杆菌提取液中分離齣DNA聚閤酶,為此,1959年,科恩伯格與他的老師、西班牙裔美國生物化學傢奧喬亞(1905~1993) 共同獲得瞭諾貝爾生理學及醫學奬。
In 1645 the Japanese samurai Musashi Miamoto wrote "A Book of Five Rings," which described the attitudes necessary for individual success. Though he was a swordsman, his book was not limited to combat but addressed the much broader question of how to achieve excellence in life through study, discipline, and planning. It is still avidly read in Japan today. Arthur Kornberg's book is a modern-day "Book of Five Rings" that replaces the medium of swordsmanship with that of biochemistry, particularly enzymology. As Kornberg describes his successive research problems, the challenges they presented, and the ultimate accomplishments that resulted, he provides us with a primer in the strategies needed to do scientific work of great significance. Moreover, these strategies are played out in the context of solving some of the great biochemical problems of the twentieth century. The ability to manipulate and alter DNA fired a revolution that forever changed the nature of biology. Arthur Kornberg is a primary architect of that revolution, arguably one of the two or three most important biologists of this time. Prior to Kornberg, genetic information and later DNA were imbued by biologists with an almost vitalistic aura. Kornberg demonstrated that DNA is a molecule synthesized by enzymes, like all other chemical constituents of the cell. More important, he trained a school of scientists who focused on and discovered many of the enzymatic activities that act on DNA. It is these enzymes in particular that allow modern "genetic engineering." "For the Love of Enzymes" does not describe a single lucky or hard-won accomplishment. Rather, it is the story of thirty years of decisive campaigns, nearly all of which led to insights of major significance. In relating his story, Kornberg never avoids the difficult question of "why": why he felt classical nutritional studies had reached a plateau, why he turned to enzymology as a discipline in which the important answers would be found, and why he believes the study of enzymes will grow ever more important as we face the new scientific frontier of brain function. This book will challenge students of biology and chemistry at all levels who want to do important work rather than simply follow popular trends. It will also delight and inform readers who wish to understand how "real" science is done, and to learn of the values that guide one of our greatest researchers.
發表於2024-11-30
For the Love of Enzymes 2024 pdf epub mobi 電子書 下載
一直追逐著人類對於自我的最前沿探索,從微生物到維生素到酶到基因再到現在的腦科學!這源自我們對自身的好奇與嚮往! Author Kornberg一位擁有卓越成就的科學傢,若不是本書,我真不知生化中那麼多記憶負擔都來自他的不懈努力。從葉酸到成為酶的鍾愛者,這一路不僅讓我看到瞭...
評分一直追逐著人類對於自我的最前沿探索,從微生物到維生素到酶到基因再到現在的腦科學!這源自我們對自身的好奇與嚮往! Author Kornberg一位擁有卓越成就的科學傢,若不是本書,我真不知生化中那麼多記憶負擔都來自他的不懈努力。從葉酸到成為酶的鍾愛者,這一路不僅讓我看到瞭...
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For the Love of Enzymes 2024 pdf epub mobi 電子書 下載