When Peter Parker was bitten by a radioactive spider, he became much more than the shy, introverted high school student he had always been. Now possessed of the proportionate strength, speed and agility of a spider, he sought to use his newfound abilities to achieve wealth and fame. But after his beloved Uncle Ben was murdered, the grief-stricken youth soon realized that with great power comes great responsibility. Now Peter wages a one-man crusade against crime...in the costumed identity of the amazing Spider-man! In DOWN THESE MEAN STREETS, a new designer drug with physically-altering side effects is sweeping through the streets of New York, leaving law enforcement completely helpless and utter chaos and destruction in its wake. As Spider-man stumbles onto the terrifying truth behind the origin of the drug, must he once again confront one of the most diabolical enemies he has ever faced?