This textbook provides an up-to-date account of the mechanisms and pathophysiology of vascular disease, and the current treatment options open to vascular surgeons. As the scientific basis of vascular disease advances rapidly, it is critical that clinicians have access to relevant information written specifically for vascular surgeons. This account reviews the impact of these scientific advances on established and emerging treatment options. Experts from Australia, North America and Europe have contributed to basic topics such as atherosclerosis, restenosis, thrombosis and haemostasis, ischaemia-reperfusion injury, sepsis, vascular haemodynamics and wound healing. More applied topics such as pain syndromes in vascular surgery and the diabetic foot are also covered in this textbook. This will be a core text for all vascular surgical trainees and is especially appropriate for advanced trainees and consultants wishing to refresh their knowledge base.