The Fayez S. Sarofim Research Building, home of The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases at The University of Texas Health Science Center at Houston, was conceived as a new model for science and research based on the themes of collaboration, place and sustainability. Designed by BNIM Architects, the building attends to form and function holistically, promoting the well-being of the users as well as their productivity. The environment is cooperative to the different types of research occurring at the facility and fosters collaboration between disciplines. The design consists of two separate wings that accommodate the functional "species" of the project--laboratory, office, auditorium and support spaces--and are tied together by connective community spaces. In keeping with contemporary ideals, this facility incorporates sustainable strategies including ample use of natural light, high fly ash concrete, exterior cladding made of terra-cotta and zinc and provisions for future photovoltaic panels. Shared spaces such as an atrium, cafe, medicinal gardens and reflecting pools further the sense of community. This volume presents the faceted methodology of designing a high-performance research facility.