This volume provides thoughtful and diverse perspectives on female adolescent sexuality. These perspectives integrate biological, cultural, and interpersonal influences on adolescent girls' sexuality, and highlight the importance of using multiple methods to investigate sexual ideation and experience. Traditional portrayals cast adolescent females as sexual gatekeepers whose primary task is to fend off boys' sexual overtures and set aside their own sexual desires in order to reduce their risks for pregnancy and sexually transmitted diseases. Yet an increasing number of thoughtful and constructive critiques have challenged this perspective, arguing for more sensitive, in-depth, multimethod investigations into the positive meanings of sexuality for adolescent girls that will allow us to conceptualize (and, ideally, advocate for) healthy sexual-developmental trajectories. Collectively, authors of this volume take up this movement and chart exciting new directions for the next generation of developmental research on adolescent female sexuality. This is the 112th volume of New Directions for Child and Adolescent Development, a journal published quarterly by Jossey-Bass.