How the Immune System Works, 5th Edition

出版者:John Wiley & Sons, Ltd

作者:Lauren M. Sompayrac

页数:151

出版时间:2015-9

价格:0

装帧:Paperback

isbn号码:9781118997772

具体描述

How the Immune System Works has helped thousands of students understand what’s in their big, thick, immunology textbooks. In his book, Dr. Sompayrac cuts through the jargon and details to reveal, in simple language, the essence of this complex subject.

In fifteen easy-to-read chapters, featuring the humorous style and engaging analogies developed by Dr. Sompayrac, How the Immune System Works explains how the immune system players work together to protect us from disease – and, most importantly, why they do it this way.

Rigorously updated for this fifth edition, How the Immune System Works includes the latest information on subjects such as vaccines, the immunology of AIDS, and cancer. A highlight of this edition is a new chapter on the intestinal immune system – currently one of the hottest topics in immunology.

Whether you are completely new to immunology, or require a refresher, How the Immune System Works will provide you with a clear and engaging overview of this fascinating subject. But don’t take our word for it! Read what students have been saying about this classic book:

"What an exceptional book! It's clear you are in the hands of an expert."

"Possibly the Best Small Text of All Time!"

http://as.wiley.com/WileyCDA/WileyTitle/productCd-EHEP003432.html

作者简介

Lauren Sompayrac, PhD

Dr. Lauren Sompayrac was born in Jacksonville. He attended the Massachusetts Institute of Technology and received a B.S. degree in physics in 1963, and a Ph.D. degree in elementary particle physics in 1969.

After two years of postdoctoral research in particle physics, he moved to Copenhagen where he was a Postdoctoral Fellow for two years at the Microbiology Institute.

Returning to the United States in 1973, he was a Postdoctoral Fellow in the Department of Pathology at the Harvard Medical School where he studied tumor viruses.

In 1976, he moved to the Department of Molecular, Cellular, and Developmental Biology at the University of Colorado to continue his work on tumor viruses, eventually rising to the rank of Research Professor before his retirement in 1998.

In retirement, he writes science books, and is the author of How the Immune System Works, published by Blackwell Science in 1999.

目录信息

Table of Contents
Acknowledgments, vii
How to Use This Book, viii
This book is neither a comprehensive text nor an exam-review tool. It is an overview of the immune system, designed to give anyone who is learning immunology a feel for how the system fits together.
Lecture 1 An Overview, 1
The immune system is a “team effort,” involving many different players who work together to provide a powerful defense against invaders. Focusing in on one player at a time makes it hard to understand the game. Here we view the action from the grandstands to get a wide-angle picture of what the immune system is all about.
Lecture 2 The Innate Immune System, 13
The innate immune system is a “hard-wired” defense that has evolved over millions of years to recognize pathogens that commonly infect humans. It provides a rapid and powerful response against “everyday” invaders.
Lecture 3 B Cells and Antibodies, 27
B cells and the antibodies they produce are part of the adaptive immune system. This defense evolves during our own lifetime to protect us against invaders that we, personally, have never encountered before.
Lecture 4 The Magic of Antigen Presentation, 42
T cells, another weapon of the adaptive immune system, only recognize invaders which are “properly presented” by specialized antigen presenting cells. This feature keeps these important cells focused on the particular attackers which they are able to defend against.
Lecture 5 T Cell Activation, 55
Before they can spring into action, T cells must be activated. This requirement helps insure that only useful weapons will be mobilized.
Lecture 6 T Cells at Work, 63
Once they have been activated, helper T cells orchestrate the immune response, and killer T cells destroy infected cells.
Lecture 7 Secondary Lymphoid Organs and Lymphocyte Trafficking, 72
B and T lymphocytes travel through secondary lymphoid organs looking for the intruders they can defend against. Once activated in the secondary lymphoid organs, B and T cells are dispatched to the particular areas of the body where they can be most useful.
Lecture 8 Restraining the Immune System, 84
The powerful weapons of the immune system must be restrained lest they become overexuberant. In addition, once an invader has been defeated, the immune system must be “reset” to prepare for future attacks.
Lecture 9 Self Tolerance and MHC Restriction, 88
T cells must be trained to focus on appropriately presented invaders, and B and T lymphocytes must learn not to attack our own bodies.
Lecture 10 Immunological Memory, 98
The innate immune system remembers pathogens which have been attacking humans for millions of years. In contrast, B and T cells remember pathogens we have encountered during our lifetime. Memory B and T lymphocytes respond more quickly and effectively to a subsequent attack by the same invader.
Lecture 11 The Intestinal Immune System, 103
The human intestines are home to trillions of bacteria, viruses, fungi, and parasites. How the immune system deals with these potentially dangerous intestinal residents, which frequently invade the tissues surrounding the intestines, is a hot topic in immunology.
Lecture 12 Vaccines, 110
Vaccines safely mimic the attack of an invader so that our immune system will be primed and ready for a future challenge by the same invader.
Lecture 13 The Immune System Gone Wrong, 116
The immune system generally does a good job of defending us without causing a lot of “collateral damage.” Sometimes, however, mistakes are made.
Lecture 14 Immunodeficiency, 126
Serious disease may result when our immune system does not operate at full strength. Humans who are infected with the AIDS virus have profoundly impaired immune systems.
Lecture 15 Cancer and the Immune System, 131
The human immune system is not very good at defending us against cancer. Indeed, there is a built-in conflict between the need to minimize the chance that its weapons will attack our own bodies, and the need to destroy wannabe cancer cells.
Glossary, 139
Here are definitions of some of the terms that immunologists use – but which “normal” people wouldn’t.
List of Acronyms and Abbreviations, 142
Immunologists are big on acronyms and abbreviations, so I’ve made a list to which you can refer.
Index, 143
· · · · · · (收起)

用户评价

坦率地说，这本书的深度和广度，让我这个非专业人士感到既兴奋又略有压力。它绝对不是一本可以囫囵吞枣读完的书。在深入探讨病原体如何逃避宿主防御的部分，作者展示了一种近乎“生物战争”的视角，详细分析了病毒、细菌如何演化出各种策略来欺骗或破坏免疫反应。这种对抗性的叙事，使得阅读体验充满了戏剧张力。然而，也正因为其内容的全面性，某些关于自身免疫性疾病的分子机制探讨，涉及了大量的基因多态性和复杂的细胞间通讯网络，阅读时必须保持高度的专注力，甚至需要时不时停下来查阅一下补充材料。但这恰恰体现了它的价值：它为你提供了一个坚实的知识基石，让你有能力去阅读更前沿的、尚未被整合进主流教材的专业文献。它就像一座知识的宝库，你每深入挖掘一层，都能发现更多精妙的构造。它要求读者投入时间，但回报是无可替代的系统性认知。

我最欣赏这本书的一点，是它所体现出的批判性思维导向。它不仅仅是在罗列“是什么”和“怎么做”，更是在探讨“为什么是这样”以及“目前还有哪些未解之谜”。在探讨某些长期存在争议的免疫学理论时，作者没有采取一言堂的态度，而是公正地呈现了不同学派的观点和支持它们的数据。例如，在关于炎症反应的调控机制上，书中清晰地对比了两种主要理论模型的优劣和适用范围。这种处理方式，极大地培养了读者的科学素养，让我意识到科学知识是不断修正和发展的过程，而不是僵化的真理。这种严谨的学术态度，使得这本书不仅是一本优秀的学习资料，更是一本值得反复参阅的思维训练手册。它鼓励读者去质疑、去探究，去理解免疫学在面对新出现的流行病威胁时，其理论体系是如何被不断检验和强化的。这种对科学方法论的强调，远比单纯记住细胞名称重要得多。

我得说，这本书在讲解复杂生理过程时的逻辑严密性和深度，是教科书级别的，但阅读体验却远超一般的学术著作。它的结构设计非常巧妙，像是为那些想深入钻研免疫调控的严肃读者量身定做。我尤其欣赏作者在描述“免疫耐受性”和“免疫记忆”这两个核心概念时所展现出的细致入微。他们没有满足于给出定义，而是深入探讨了这些机制背后的信号通路和分子开关是如何被精确控制的。比如，在解释疫苗如何诱导持久免疫力时，书中对生发中心反应的描述，简直是一幅精妙的细胞互动画卷，包含了滤泡辅助性T细胞（Tfh）与B细胞之间复杂的“情书往来”。更令人称道的是，作者毫不避讳地讨论了免疫系统在癌症治疗和器官移植中所面临的挑战和前沿研究方向。每当涉及最新的科研突破时，作者总能迅速地将其置于已建立的知识框架中进行评述，而不是孤立地介绍新发现。这种将基础科学与临床应用紧密结合的方式，让阅读过程充满了前瞻性和紧迫感，让我感觉手中的书本不仅仅是在回顾历史，更是在展望未来医学的蓝图。

这本关于免疫系统的书，真是让我打开了新世界的大门。我原本对生物学领域里的复杂概念总是望而却步，觉得那些基因、细胞、蛋白之类的名词简直是天书。然而，作者的叙事方式极其平易近人，仿佛在跟一个完全没有基础的朋友聊天。他们没有一上来就抛出那些令人头皮发麻的专业术语，而是从宏观的角度，比如“我们的身体是如何构建起一道看不见的防御城墙的？”这种引人入胜的问题切入。我特别欣赏它对历史背景的梳理，讲述了早期的科学家们是如何一步步揭开免疫学神秘面纱的，那些早期的实验设计，在今天看来或许简陋，却充满了智慧和坚韧。阅读过程中，我感觉自己不再是被动接受知识，而是在参与一场侦探式的探索，试图理解那些微小的免疫细胞是如何协同作战，识别并清除入侵者的。书中对T细胞和B细胞功能的阐述，通过生动的比喻和清晰的图示，将原本抽象的分子机制变得具体可感。即便是那些关于补体系统的复杂级联反应，也被拆解成了易于消化的步骤。读完后，我对日常生活中感冒、过敏乃至自身免疫性疾病的发生机制，都有了一种全新的、更为深刻的理解，这绝不是那种教科书式的干巴巴的描述。

这本书的排版和视觉呈现，简直是为视觉学习者福音。我常常发现，很多关于细胞信号传导的书籍，充斥着密密麻麻的文字，让人读了三页就想放弃。但这本作品完全不同。它的插图质量极高，而且更重要的是，这些图表的设计并非仅仅是装饰品，它们是叙事的关键组成部分。例如，当描述淋巴结内部的“行军路线图”时，作者使用的三维示意图清晰地标示了不同细胞群的“家园”和它们的迁移路径，这比单纯的文字描述效率高出百倍。我特别留意到，作者在引用关键实验或概念时，总是会附带一个精心设计的流程图，用箭头和不同颜色清晰地界定了因果关系。这些视觉辅助工具，成功地将原本需要反复研读才能理解的动态过程，转化为一目了然的静态信息。对于我这种需要反复对照图文才能彻底理解复杂生物网络的人来说，这种对视觉清晰度的极致追求，极大地减轻了学习负担，也让我在回顾知识点时，能迅速定位到核心的结构关系上。

我现在觉得看这种原版课本比看小说更好，语句通俗易懂，只要搞定若干术语，基本上就没什么阅读障碍，还能学到各种知识

The first book, touched me, about medicine. From cluelessness, knowledge’s made through hypothesizes, tests, on animals and humans, and repeated failures with pain and wait. It’s humorously written, with respects to ‘Mother Nature.’ We learn how we were made, and cope with it. In the end, we’re Created, like other animals.

免疫学入门必读神作。

The first book, touched me, about medicine. From cluelessness, knowledge’s made through hypothesizes, tests, on animals and humans, and repeated failures with pain and wait. It’s humorously written, with respects to ‘Mother Nature.’ We learn how we were made, and cope with it. In the end, we’re Created, like other animals.

免疫学入门必读神作。