In Knowing the Structure of Nature, Stathis Psillos develops the articulation and defence of scientific realism that started in his very influential, widely read and discussed Scientific Realism: How Science Tracks Truth. Psillos argues in favour of the epistemic optimism associated with scientific realism. He criticises attempts to draw a sharp epistemic dichotomy between those aspects of nature that are knowable and those that will remain secret--attempts to set limits to the scientific knowledge of nature. The book focuses on recent arguments and views in the scientific realism debate and repositions this debate within broader metaphysical and epistemological perspectives. It takes issue with key elements of the structuralist turn in the philosophy of science and advances a new framework for inference to the best explanation. Professional philosophers of science, graduate students and anyone interested in scientific realism and inference to the best explanation will find this book rewarding, stimulating and provocative.