Preface
Chapter 1. The Diagram Method: States
1.1 Introduction
1.2 Diagrams for Steady-State (and Equilibrium) Systems
1.3 Directional Diagrams and the Steady-State Populations of States
1.4 Simple Examples of the Use of Directional Diagrams
1.5 Transition Fluxes and Probabilities of States
References
Chapter 2. The Diagram Method: Cycles
2.1 Cycles and Cycle Fluxes
2.2 One-Way Cycle Fluxes; Kinetics at the Cycle Level
2.3 Further Examples of Cycles and of Flux Diagrams
2.4 Calculation of State Probabilities from Cycle Fluxes
References
Chapter 3: Fluxes and Forces
3.1 Example: Membrane Transport of Two Ligands
3.2 Substrate-Product Rate Constant Relations
3.3 Example: Active Transport of Na+ and K+
3.4 Reciprocal Relations and Irreversible Thermodynamics
References
Chapter 4: Free Energy Levels of Macromolecular States
4.1 Free Energy Levels of the States
4.2 Single-Cycle Examples
4.3 Simple Multicycle Example with Two Forces
4.4 Enzyme-Substrate Modified by Ligand
References
Chapter 5: Muscle Contraction
5.1 General Principles
5.2 The Kinetic Formalism
5.3 Entropy Production and Directional Properties
5.4 Current Status of Muscle Models
5.5 Free Energy Transfer in Muscle Contraction
References
Chapter 6: Stochastics and Fluctuations at Cycle and State Levels
6.1 Stochastics of Cycle Completion
6.2 Some Further Stochastic Considerations in Muscle Contraction
6.3 State Stochastics: A Two-State System
6.4 State Stochastics: Arbitrary Diagram
References
Chapter 7: Interacting Subsystems and Multienzyme Complexes
7.1 Example: Two-Enzyme Complex
7.2 Example: Three-Enzyme Complex
7.3 Example: Two Interacting Enzymes
7.4 Oxidative Phosphorylation
References
Appendix 1. "Reduction" of a Diagram
Appendix 2. Diagram Solution for the Nix; Flux Diagrams
Appendix 3. Charged Ligand and Membrane Potential
Appendix 4. Some Properties of Single-Cycle Diagrams
Appendix 5. Light Absorbing (and Emitting) Systems
Appendix 6. Basic and Gross Free Energy Levels in a Simple Special Case
Index
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