Hellboy is called to Amalfi, Italy, by Franca, a young member of the Esposito family. She fears that a dark curse on her family is about to claim her cousin as its next victim. Hellboy makes his way to their large home, and he encounters a flaming demon - a fire wolf - which he successfully fights off. Hellboy and Franca make their way to Pompeii, where Franca remembers seeing an image of the fire wolf whilst on an archaeological dig. Hellboy unearths the shriveled corpse of a demon hunter who was buried during the AD 79 eruption of Vesuvius, and it tells him of the fire-demon that escaped the grip of the volcano leading to that devastating eruption. Attacked again by the fire wolf, Hellboy and Franca have to make their way back to Amalfi to confront Adamo Esposito, the family elder. But already the volcano is rumbling again, and an eruption even more devastating than that historical catastrophe looks very, very close!