As a reversible cause of obesity, Cushinga (TM)s syndrome is increasingly considered in the differential diagnosis of obese patients. This volume will review the difficulties in distinguishing Cushinga (TM)s syndrome from these and other common conditions, such as menstrual irregularity and depression. It will provide all the up to date information on various strategies to establish the diagnosis of Cushinga (TM)s syndrome. Additionally, conditions that represent challenges for the diagnosis, such as renal failure, pediatric age, cyclic hypercortisolism and pregnancy, will be considered. Cushinga (TM)s syndrome is caused by a variety of conditions, and its treatment differs according to the etiology. Approaches to the differential diagnosis and specific treatments for each condition will be provided. Chapters that discuss controversies in diagnosis and differential diagnosis will provide a nuanced perspective of these areas.