Change is inevitable in this global environment. The "business as usual" sentiments are now past memories. Organizations, both profit and non-profit, are being challenged to find new and better ways to compete in their marketplaces. At the forefront of this challenge is the need to be prepared and deal with significant change that is considered frame-breaking, radical, and revolutionary. Those who rise and willingly accept the challenge of dealing with this culture-influencing phenomenon will increase their chances to maintain a competitive edge. This book identifies the issues of significant change and provides some considerations in preparing for an organizational transformation. Based on both qualitative and quantitative research, the methods provide support of the findings. The material presented will aid those who are involved with significant change to gain a better understanding of the underlying subject matter, as well as identify strategies to turn challenges into opportunities.