This volume in the HANDBOOK OF CLINICAL NEUROLOGY (Series Editors: Michael J. Aminoff, Department of Neurology, University of California, San Francisco, USA; François Boller, Bethesda, USA; Dick F. Swaab, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands) deals with neuropathology, physiopathology, biology, clinics, and imaging of all or most dementing disorders that are presently known. It also includes chapters on the legal and ethical issues to give the health care worker a general view on diseases that are not only scientific riddles, but also the cause of affliction of many patients and of their families. Recently several major new advances in understanding have been made and are covered in this volume (for example the progranulin mutation and the role of TDP-43). All those dealing with dementia, at whatever level of expertise, may find this volume of value.