The boy in the bed was just fifteen years old. He had been handsome, perhaps even recently; but now his face was swollen and disfigured by disease, and by the treatments his doctors had prescribed in the attempt to ward off its ravages. Their failure could no longer be mistaken. When Edward VI - Henry VIII's longed-for son - died in 1553, extraordinarily, there was no one left to claim the title King of England. For the first time, all the contenders for the crown were female. In 1553, England was about to experience the 'monstrous regiment' - the unnatural rule - of a woman. But female rule in England also had a past. Four hundred years before Edward's death, Matilda, daughter of Henry I and granddaughter of William the Conquerer, came tantalisingly close to securing her hold on the power of the crown. And between the 12th and the 15th centuries three more exceptional women - Eleanor of Aquitaine, Isabella of France, and Margaret of Anjou - discovered, as queens consort and dowager, how much was possible if the presumptions of male rule were not confronted so explicitly. The stories of these women - told here in all their vivid humanity - illustrate the paradox which the female heirs to the Tudor throne had no choice but to negotiate. Man was the head of woman; and the king was the head of all. How, then, could a woman be king, how could royal power lie in female hands?