The Cancer Treatment Revolution

The Cancer Treatment Revolution pdf epub mobi txt 电子书 下载 2026

出版者:John Wiley & Sons Inc
作者:Nathan M.D., David G.
出品人:
页数:272
译者:
出版时间:2007-3
价格:180.00元
装帧:HRD
isbn号码:9780471946540
丛书系列:
图书标签:
  • david-nathan
  • 癌症治疗
  • 肿瘤学
  • 医学
  • 健康
  • 癌症研究
  • 创新疗法
  • 个性化医疗
  • 免疫疗法
  • 靶向治疗
  • 临床试验
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具体描述

Praise for The Cancer Treatment Revolution "A wonderful journey through modern medical science, told with warmth and insight, brought to life through the stories of people confronting cancer. This book will inspire and educate both laymen and caregivers."

—Jerome Groopman, M.D., author of The Measure of Our Days and The Anatomy of Hope and Recanati , Professor, Harvard Medical School "This is probably the best book on cancer that exists--beautifully written and unfailingly interesting, conveying a clear sense of hope for cancer patients and survivors. Cancer treatment has come a long way but not without intense struggles and passions, which David Nathan narrates from the inside as one of the leading players. He explains cancer more clearly than anyone else, and his portraits of great cancer doctors are sharp and unforgettable, a contribution to history."

—Richard Preston, author of The Hot Zone and The Demon in the Freezer "No one is better positioned to tell the tale of the cancer treatment revolution of the last half century than David Nathan. A brilliant physician-scientist, he has been present at the cusps of history in this life-and-death field. The story he tells here is fascinating, and his book is captivating."

—Atul Gawande, M.D., author of Complications: A Surgeon's Notes on an Imperfect Science and Better: A Surgeon's Notes on Performance and Assistant Professor of Surgery, Harvard Medical School "David Nathan is a true storyteller. In The Cancer Treatment Revolution , he tells stories that bridge cancer patients and cancer research as few others could. These gripping tales will be appreciated by those who live with cancer and those who strive to create new therapies."

—Thomas Cech, Ph.D., recipient of the 1989 Nobel Prize in Chemistry and President of the Howard Hughes Medical Institute "David Nathan, one of the nation's preeminent clinician-scientists, tells the stories of three cancer patients, revealing compelling human facets--the dedication of the remarkable teams that care for these patients and, even more, the bravery and fortitude of the patients and their families."

—Harold Varmus, M.D., recipient of the 1989 Nobel Prize in Medicine, President of the Memorial Sloan-Kettering Cancer Center, and former director of the National Institutes of Health "Engaged by the compelling triumphs and tragedies of patients whose normal lives are inevitably altered by a life-threatening cancer, the reader of The Cancer Treatment Revolution will easily appreciate the impact of the new cancer diagnostics and therapies compared to even relatively recent cancer treatments."

—Karen Antman, M.D., Dean, Boston University School of Medicine "This personal, highly readable account by one of the leaders of the cancer treatment revolution explains how the revolution has come about and how it will change the future."

—Sir Paul Nurse, Ph.D., President of Rockefeller University and recipient of the 2001 Nobel Prize in Medicine

《癌症治疗革命》并非一本详述具体癌症治疗方法的书,而是一场关于我们如何理解、对抗乃至终结癌症的思维与实践的全面革新。它描绘了一幅宏伟的蓝图,勾勒出医学、科学、技术以及社会力量如何汇聚,共同铸就一场深刻的变革。 本书不关注某一种特定疗法的技术细节,而是聚焦于驱动这场革命的核心理念和关键驱动力。它首先深入剖析了癌症本身复杂的、动态的本质。从遗传突变到微环境影响,从免疫逃逸到转移机制,本书旨在打破对癌症的简单化认知,揭示其作为一种复杂疾病的真实面貌。这种对癌症本质的深刻理解,正是所有革命性突破的基石。 接着,《癌症治疗革命》将目光投向了新一代的治疗策略。这并非简单的药物列表,而是对那些颠覆传统思维的治疗模式的探索。例如,它将深入探讨精准医疗的崛起,不仅仅是基因检测,而是如何利用个体化的生物学信息,为每位患者量身定制最有效的治疗方案。这包括对肿瘤基因组、蛋白质组、甚至微生物组的深度分析,从而找到驱动癌症发展的“弱点”。 本书还会详细阐述免疫疗法的飞跃式发展。它会超越PD-1/PD-L1抑制剂的范畴,去探寻激活人体自身免疫系统对抗癌症的更多前沿策略。这可能包括CAR-T细胞疗法在实体瘤中的突破,双特异性抗体如何同时攻击癌细胞和免疫细胞,以及肿瘤疫苗如何训练免疫系统识别和摧毁癌细胞。更重要的是,它将探讨如何克服免疫疗法的耐药性,以及如何将免疫疗法与其他治疗手段相结合,产生协同效应。 此外,《癌症治疗革命》还会审视靶向治疗的演进。它会分析如何发现新的、更精确的分子靶点,如何应对靶点突变带来的耐药性,以及如何开发能够克服血脑屏障等挑战的药物。这本书将揭示,靶向治疗早已超越了单一基因的限制,而是更加关注信号通路和网络。 本书的一大亮点在于,它将重点关注那些尚未被广泛认知但极具潜力的领域。这包括对微环境调控的深入研究,理解肿瘤微环境如何影响癌细胞的行为和治疗反应,以及如何通过干预微环境来增强治疗效果。它还会触及代谢疗法,即通过改变癌细胞的代谢途径来抑制其生长,这是一种全新的治疗思路。 《癌症治疗革命》同样会关注早期诊断与预防的进步。它会探讨液体活检、人工智能在影像学诊断中的应用,以及基因组学在识别高危人群中的作用。有效的治疗始于早期发现,而这场革命,也必然包含着将癌症扼杀在萌芽状态的努力。 更重要的是,本书将深入探讨技术创新在驱动这场革命中所扮演的角色。例如,人工智能(AI)如何在药物研发、临床试验设计、患者数据分析等方面发挥关键作用。基因编辑技术(如CRISPR)如何为开发新型基因疗法提供可能。大数据和云计算如何整合庞杂的生物学和临床数据,从而加速科学发现。 《癌症治疗革命》还将触及临床试验的变革。它会分析如何设计更有效、更快速的临床试验,如何利用真实世界数据来辅助研究,以及如何吸引更多患者参与到这些前沿研究中来。 最后,本书将不仅仅局限于科学和医学本身,还会探讨社会、伦理和经济因素如何影响癌症治疗的进步。它会讨论如何确保新疗法的可及性和可负担性,如何应对数据隐私和伦理挑战,以及如何建立一个支持创新和合作的生态系统。 总而言之,《癌症治疗革命》是一部关于我们如何以全新的视角、更强大的工具和更深刻的理解来应对癌症的宏大叙事。它描绘的是一个我们正以前所未有的速度和决心,一步步迈向“癌症不再是绝症”的未来。它是一场关于希望、关于智慧、关于不懈追求的深刻见证,激励着每一个人参与到这场改变命运的征程中来。

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