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John Parrington, University Lecturer in Pharmacology, University of Oxford

John Parrington is an Associate Professor in Molecular and Cellular Pharmacology at the University of Oxford, and a Tutorial Fellow in Medicine at Worcester College, Oxford. He has published over 80 peer-reviewed articles in science journals including Nature, Current Biology, Journal of Cell Biology, Journal of Clinical Investigation, The EMBO Journal, Development, Developmental Biology, and Human Reproduction. He has extensive experience writing popular science, having published articles in The Guardian, New Scientist, Chemistry World, and The Biologist. He has also written science reports for the Wellcome Trust, British Council, and Royal Society. He is the author of The Deeper Genome, (OUP, 2015).

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发表于2024-05-15

Redesigning Life 2024 pdf epub mobi 电子书

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出版者:Oxford University Press

作者:John Parrington

出品人:

页数:320

译者:

出版时间:2016-10-25

价格:USD 39.95

装帧:Hardcover

isbn号码:9780198766827

丛书系列:

图书标签: 基因科普英文原版书生物学 neuroscience

Redesigning Life 2024 pdf epub mobi 电子书图书描述

Since the birth of civilisation, human beings have manipulated other life-forms. We have selectively bred plants and animals for thousands of years to maximize agricultural production and cater to our tastes in pets. The observation of the creation of artificial animal and plant variants was a key stimulant for Charles Darwin's theory of evolution. The ability to directly engineer the genomes of organisms first became possible in the 1970s, when the gene for human insulin was introduced into bacteria to produce this protein for diabetics. At the same time, mice were modified to produce human growth hormone, and grew huge as a result. But these were only our first tottering steps into the possibilities of genetic engineering.

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In the past few years, the pace of progress has accelerated enormously. We can now cut and paste genes using molecular scissors with astonishing ease, and the new technology of genome editing can be applied to practically any species of plants or animals. 'Mutation chain reaction' can be used to alter the genes of a population of pests, such as flies; as the modified creatures breed, the mutation is spread through the population, so that within a few generations the organism is almost completely altered. At the same time, scientists are also beginning to synthesize new organisms from scratch.

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These new technologies hold much promise for improving lives. Genome editing has already been used clinically to treat AIDS patients, by genetically modifying their white blood cells to be resistant to HIV. In agriculture, genome editing could be used to engineer species with increased food output, and the ability to thrive in challenging climates. New bacterial forms may be used to generate energy. But these powerful new techniques also raise important ethical dilemmas and potential dangers, pressing issues that are already upon us given the speed of scientific developments. To what extent should parents be able to manipulate the genetics of their offspring - and would designer babies be limited to the rich? Can we effectively weigh up the risks from introducing synthetic lifeforms into complex ecosystems? John Parrington explains the nature and possibilities of these new scientific developments, which could usher in a brave, new world. We must rapidly come to understand its implications if we are to direct its huge potential to the good of humanity and the planet.

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一般而言，学习一个专业需要好好研读其教科书，继而是paper，但是这样做的缺点有二，一是枯燥无趣（很不幸，99%的教科书都如此），二是时间投入大，因此这种最踏实稳定的做法实际上不一定是最佳选择，尤其是对于阅读需求只为大致了解相应领域进展，并非进入该专业工作实践的读者。这本书可以使缺乏生物专业背景的你尽览近年来基因遗传学的惊人突破，包括最为红火的光遗传学和“魔剪”技术。内容的套路是这样的：小故事作为开端引出某技术、解释技术的简单原理、介绍技术的代表性研究实验、讲解实验的意义与其在未来的进一步可能性、穿插八卦或科幻的科学基础。看似常规，但在具备极高阅读趣味性的同时，专业性亦得到保障，精彩叙述加上恰当好处的配图，看似脑洞但不乏实现可能的各种奇迹，最后带出的大量道德两难问题，可谓相应领域科普第一书。

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