Christine Vachon (b. 1962, Manhattan, New York City) is an American movie producer active in the US independent film sector and daughter of noted photographer John Vachon.

Christine Vachon produced Todd Haynes' controversial first feature, Poison, which was awarded the Grand Jury Prize at the 1991 Sundance Film Festival. Since then, she has gone on to produce many acclaimed American independent films including Far From Heaven (nominated for four Academy Awards), Boys Don't Cry (Academy Award winner), One Hour Photo, Hedwig and the Angry Inch, Happiness, Velvet Goldmine, SAFE, I Shot Andy Warhol, Go Fish, Swoon, I'm Not There, Gigantic, Cracks. and Cairo Time. Her latest and upcoming projects include a short film collaboration with ACE Hotel and online film content producers Massify entitled "Lulu at the Ace Hotel" as well as a five-part HBO mini-series adaptation of James M. Cain's 1941 novel, Mildred Pierce.