Multiple Testing Procedures with Applications to Genomics

出版者:Springer Verlag

作者:Dudoit, Sandrine/ Van Der Laan, Mark J.

页数:623

出版时间:2007-10

价格:$ 134.47

装帧:HRD

isbn号码:9780387493169

图书标签:美国统计科技数学教材statisticsgeneR

This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. These are applied to a range of problems in biomedical and genomic research, including identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments; tests of association between gene expression measures and biological annotation metadata; sequence analysis; and genetic mapping of complex traits using single nucleotide polymorphisms. The procedures are based on a test statistics joint null distribution and provide Type I error control in testing problems involving general data generating distributions, null hypotheses, and test statistics.