This is the inaugural volume for a new annual review serving the medical genetics community. This annual volume will feature in-depth scholarly reviews of the most timely and important topics and issues affecting this field. Special Offer from the New York Academy of Sciences: Order thisvolume at adiscountand become a NYAS IndividualMember free. Click here to find out more on the NYAS site. Follow the instructions for adding individual membership to your shopping cart and choose this volume, which will show as being free. Offer not applicable in conjunction with a Student & Postdoc Membership. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.