The Picornaviruses

作者:Ehrenfeld, Ellie; Domingo, Esteban; Roos, Raymond P.

页数:540

出版时间:2010

价格:$ 259.84

装帧:精装

isbn号码:9781555816032

具体描述

Picornaviruses afflict the animal kingdom with a wide range of maladies, notably the common cold, encephalitis, hepatitis, meningitis, and polio in humans and the economically devastating foot-and-mouth disease in animals. With contributions from leading experts from around the world, this volume examines the most current breakthroughs as well as the challenges that lie ahead in picornavirus research. Based on the most recent basic and clinical research findings, The Picornaviruses encapsulates our current knowledge of the molecular biology, evolution, and pathogenesis of this large family of viruses. In addition, it examines the diseases that these viruses cause and the latest vaccines and antiviral drugs to prevent and control those diseases.

The first eleven chapters explore the structural and mechanistic bases of picornavirus replication, highlighting new insights about the host cell interactions needed for virus growth. The next six chapters illustrate how the regular occurrence of mutations, typical of viruses with RNA as genetic material, generates the quasispecies dynamics that underlie viral fitness. Together with more drastic recombination events, the book shows how this error-prone RNA replication may have generated the variety of viruses embodied in the different picornavirus genera. The final twelve chapters focus on picornaviruses that cause disease, examining pathogenicity and innate and acquired immune responses against infection as well as the latest vaccine and antiviral drug strategies.

Synthesizing the latest developments in the study of picornaviruses, the book underscores our growing understanding of the close connections among picornavirus biology, diversity, evolution, and disease. Moreover, it serves as a springboard for developing new approaches to understanding this important family of viruses as well as preventing and treating picornaviral diseases.

Hardcover, 493 pages, full-color insert, illustrations, index.

作者简介

Vadim I. Agol

Institute of Poliomyelitis and Viral Encephalitides, Russian Academy of Medical Sciences, Kievskoye Shosse 27 km., Moscow Region 142782, Russia

Rubén Agudo

Centro de Biología Molecular Severo Ochoa, CSIC-UAM, C/Nicolás Cabrera 1, Cantoblanco, Universidad Autónoma de Madrid, Madrid 28049, Spain

Raul Andino

Mission Bay Genentech Hall, Microbiology and Immunology, University of California, San Francisco, 600 16th Street, Room S572E, Box 2280, San Francisco, CA 94143-2280

Armando Arias

Centro de Biología Molecular Severo Ochoa, CSIC-UAM, C/Nicolás Cabrera 1, Cantoblanco, Universidad Autónoma de Madrid, Madrid 28049, Spain

George Belov

Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Room 126, Rockville, MD 20852

Jeffrey M. Bergelson

Division of Infectious Diseases, Abramson 1202, Children’s Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, PA 19104

Albert Bosch

Department of Microbiology, University of Barcelona, Ave. Diagonal 645, Barcelona 08028, Spain

Mihnea Bostina

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115

Nora M. Chapman

Department of Pathology and Microbiology, University of Nebraska Medical Center, 986495 Nebraska Medical Center, Omaha, NE 68195-6495

Konstantin Chumakov

Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, HFM-470, Rockville, MD 20852

Florence Colbère-Garapin

Biologie des Virus Enteriques, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris cedex 15, and INSERM U994 Paris, France

Teresa de los Santos

Plum Island Animal Disease Center, North Atlantic Area, Agricultural Research Service, U.S. Department of Agriculture, P.O. Box 848, Greenport, NY 11944

Armando M. De Palma

Laboratory of Virology and Chemotherapy, Department of Microbiology and Immunology, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium

Esteban Domingo

Centro de Biología Molecular Severo Ochoa CSIC-UAM, C/Nicolás Cabrera 1, Cantoblanco, Universidad Autónoma de Madrid, Madrid 28049, Spain

Jonathan D. Dougherty

Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030

Ellie Ehrenfeld

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-8011

Cristina Escarmís

Centro de Biología Molecular Severo Ochoa CSIC-UAM, C/Nicolás Cabrera 1, Cantoblanco, Universidad Autónoma de Madrid, Madrid 28049, Spain

Zongdi Feng

Division of Infectious Diseases, Department of Medicine, and the Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295

Cristina Ferrer-Orta

Institut de Biología Molecular de Barcelona, Parc Científic de Barcelona, Baldiri i Reixac 10, 08028 Barcelona, Spain

David J. Filman

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115

Elizabeth E. Fry

Division of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Headington, Oxford OX3 7BN, United Kingdom

Robert S. Fujinami

Department of Pathology, University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, UT 84132

Alexander E. Gorbalenya

Department of Medical Microbiology, Leiden University Medical Center, Postzone E4-P, P.O. Box 9600, NL-2300 RC Leiden, The Netherlands

Marvin J. Grubman

Plum Island Animal Disease Center, North Atlantic Area, Agricultural Research Service, U.S. Department of Agriculture, P.O. Box 848, Greenport, NY 11944

Kurt E. Gustin

Department of Basic Medical Sciences, University of Arizona College of Medicine, 425 N. Fifth Street, Phoenix, AZ 85004

Marc B. Hershenson

Department of Pediatrics and Communicable Diseases, C. S. Mott Children’s Hospital, University of Michigan Medical School, Ann Arbor, MI 48109

James M. Hogle

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115

Tapani Hovi

National Institute for Health and Welfare (THL) P.O. Box 30 FI-00271 Helsinki, Finland

Christopher C. Kemball

Department of Immunology and Microbial Science SP30-2110, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037

Olen Kew

Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333

Andrew M. Q. King

Institute for Animal Health, Pirbright Laboratory, Pirbright, Woking, Surrey GU24 0NF, United Kingdom

Karla Kirkegaard

Department of Microbiology and Immunology, Fairchild Science Building D309A, Stanford University School of Medicine, Stanford, CA 94305-5402

Nick J. Knowles

Institute for Animal Health, Pirbright Laboratory, Pirbright, Woking, Surrey GU24 0NF, United Kingdom

Satoshi Koike

Neurovirology Project, Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan

Chris Lauber

Department of Medical Microbiology, Leiden University Medical Center, Postzone E4-P, P.O. Box 9600, NL-2300 RC Leiden, The Netherlands

Stanley M. Lemon

Division of Infectious Diseases, Department of Medicine, and the Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295

Hazel Levy

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115

Howard L. Lipton

Department of Microbiology & Immunology, MC790, University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, IL 60612-7344

Richard E. Lloyd

Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030

Encarna Martínez-Salas

Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Nicolás Cabrera 1, Cantoblanco, Madrid 28049, Spain

Thomas Michiels

de Duve Institute, Université Catholique de Louvain, 74 avenue Hippocrate, B-1200 Brussels, Belgium

Philip D. Minor

Division of Virology, National Institute for Biological Standards and Control (NIBSC), Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, United Kingdom

Steffen Mueller

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794

David Neubauer

Max F. Perutz Laboratories, Medical University of Vienna, Dr. Bohr-Gasse 9/3, A-1030 Vienna, Austria

Johan Neyts

Rega Institute, Minderbroedersstraat 10, B-3000 Leuven, Belgium

Akio Nomoto

Institute of Microbial Chemistry, 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo 141-0021, Japan

Ann Palmenberg

Institute for Molecular Virology, University of Wisconsin—Madison, 1525 Linden Drive, Madison, WI 53706

Nogi Park

Department of Basic Medical Sciences, University of Arizona College of Medicine, 425 N. Fifth Street, Phoenix, AZ 85004

Aniko V. Paul

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794

Celia Perales

Centro de Biología Molecular Severo Ochoa, CSIC-UAM, C/Nicolás Cabrera 1, Cantoblanco, Universidad Autónoma de Madrid, Madrid 28049, Spain

Rosa M. Pintó

Department of Microbiology, University of Barcelona, Av. Diagonal 645, Barcelona 08028, Spain

Vincent R. Racaniello

Department of Microbiology & Immunology, Columbia University College of Physicians & Surgeons, Room 1310B, 701 W. 168th Street, New York, NY 10032

Luis L. Rodriguez

Plum Island Animal Disease Center, North Atlantic Area, Agricultural Research Service, U.S. Department of Agriculture, P.O. Box 848, Greenport, NY 11944

Raymond P. Roos

Department of Neurology/MC2030, The University of Chicago Medical Center, 5841 S. Maryland Ave., Chicago, IL 60637

David J. Rowlands

Institute for Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom

Janet M. Rozovics

Department of Microbiology and Molecular Genetics, School of Medicine, Medical Sciences I, B214, University of California, Irvine, Irvine, CA 92697-4025

Martin D. Ryan

Centre for Biomolecular Sciences, University of St. Andrews, North Haugh, St. Andrews, Fife, Scotland, KY16 9ST, United Kingdom

Bert L. Semler

Department of Microbiology and Molecular Genetics, School of Medicine, Medical Sciences I, B237, University of California, Irvine, CA 92697-4025

Peter Simmonds

Centre for Infectious Diseases, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, United Kingdom

Tim Skern

Max F. Perutz Laboratories, Medical University of Vienna, Dr. Bohr-Gasse 9/3, A-1030 Vienna, Austria

Glyn Stanway

Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex C04 3SQ, United Kingdom

David I. Stuart

Division of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Headington, Oxford OX3 7BN, United Kingdom

Steven Tracy

Department of Pathology and Microbiology, University of Nebraska Medical Center, 986495 Nebraska Medical Center, Omaha, NE 68195-6495

Frank van Kuppeveld

Department of Medical Microbiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, P.O. Box 9101 (internal post 268), 6500 HB Nijmegen, The Netherlands

Nuria Verdaguer

Institut de Biología Molecular de Barcelona, Parc Científic de Barcelona, Baldiri i Reixac 10, 08028 Barcelona, Spain

Marco Vignuzzi

Viral Populations and Pathogenesis, Institut Pasteur, 75724 Paris cedex 15, France

J. Lindsay Whitton

Department of Immunology and Microbial Science, SP30-2110, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037

Eckard Wimmer

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794

目录信息

Contributors
Preface
I. Introduction to Picornavirus Biology
1. Genome Organization and Encoded Proteins
Ann Palmenberg, David Neubauer, and Tim Skern
2. Overview of Taxonomy
Nick J. Knowles, Tapani Hovi, Andrew M. Q. King, and Glyn Stanway
3. The Making of a Picornavirus Genome
Eckard Wimmer and Aniko V. Paul
II. Virion Structure and Cell Entry and Assembly
4. Virion Structure
Elizabeth E. Fry and David I. Stuart
5. Receptors
Jeffrey M. Bergelson
6. Cell Entry: a Biochemical and Structural Perspective
Hazel Levy, Mihnea Bostina, David J. Filman, and James M. Hogle
III. Genome Replication and Translation
7. Genome Replication I: the Players
Janet M. Rozovics and Bert L. Semler
8. Genome Replication II: the Process
Karla Kirkegaard and Bert L. Semler
9. Translation and Protein Processing
Encarna Martínez-Salas and Martin D. Ryan
IV. Alterations of Host Cell Function
10. Interference with Cellular Gene Expression
Jonathan D. Dougherty, Nogi Park, Kurt E. Gustin, and Richard E. Lloyd
11. Remodeling Cellular Membranes
Frank van Kuppeveld, George Belov, and Ellie Ehrenfeld
V. Evolution and Mechanisms
12. Mutation, Quasispecies, and Lethal Mutagenesis
Esteban Domingo, Celia Perales, Rubén Agudo, Armando Arias, Cristina Escarmís, Cristina Ferrer-Orta, and Nuria Verdaguer
13. Biological Implications of Picornavirus Fidelity Mutants
Marco Vignuzzi and Raul Andino
14. Recombination in the Evolution of Picornaviruses
Peter Simmonds
15. Picornaviruses as a Model for Studying the Nature of RNA Recombination
Vadim I. Agol
16. Origin and Evolution of the Picornaviridae Proteome
Alexander E. Gorbalenya and Chris Lauber
17. Codon Biases and Viral Fitness
Albert Bosch, Steffen Mueller, and Rosa M. Pintó
VI. Immune Response and Persistence
18. Innate Immune Responses
Vincent R. Racaniello
19. Adaptive Immune Responses
Christopher C. Kemball, Robert S. Fujinami, and J. Lindsay Whitton
20. Persistent Infections
Florence Colbère-Garapin and Howard L. Lipton
VII. Pathogenesis of Disease
21. Poliomyelitis
Satoshi Koike and Akio Nomoto
22. Group B Coxsackievirus Diseases
Steven Tracy and Nora M. Chapman
23. Rhinovirus and Respiratory Disease
Marc B. Hershenson
24. Hepatitis A Virus
Zongdi Feng and Stanley M. Lemon
25. Foot-and-Mouth Disease
Marvin J. Grubman, Luis L. Rodriguez, and Teresa de los Santos
26. Theiler’s Virus Central Nervous System Infection
Thomas Michiels and Raymond P. Roos
VIII. Disease Prevention and Treatment
27. Vaccine Strategies
David J. Rowlands and Philip D. Minor
28. The Poliovirus Eradication Initiative
Konstantin Chumakov and Olen Kew
29. Antiviral Drugs
Armando M. De Palma and Johan Neyts
Index
Color Plates
· · · · · · (收起)

用户评价

我得说，《The Picornaviruses》在病毒学文献的引用规范和数据呈现上，达到了令人发指的专业水准。我几乎找不到任何一处数据图表是含糊不清或者缺乏必要的统计学支撑的。对于任何一个需要撰写综述或研究论文的人而言，这本书本身就是一个关于如何规范展示科学证据的范本。特别是关于结构生物学的部分，那些利用冷冻电镜（Cryo-EM）技术解析的病毒颗粒三维重建图，其清晰度和细节程度，让我这个业余爱好者都感到震撼。你可以清晰地分辨出VP1、VP2、VP3、VP4这四个主要衣壳蛋白在自组装过程中的空间关系。作者在讨论病毒感染过程中，对宿主蛋白的“绑架”机制时，非常擅长使用对比论证，将不同物种间宿主因子差异对病毒感染效率的影响进行了细致的对比分析。这种跨物种比较的视野，极大地拓展了我对病毒-宿主互作复杂性的理解。它不是一本“速成”读物，而是一本需要反复研读、随时查阅的“案头书”。

这本书的结构编排，说实话，有些许“古朴”，但这种“古朴”反而体现了一种经典学术著作的厚重感和严谨性。它的章节划分似乎更侧重于病毒学的传统分类逻辑，而非时下热门的信号通路交叉点。一开始的几章对Picornaviridae 家族的分类学历史回顾，内容极其详尽，引用了大量的早期文献，读起来就像是在翻阅一部家族族谱，你需要耐心去梳理那些命名变更和亚型划分的细微差别。不过，一旦你跨过了这些基础性的“门槛”，后续的章节质量便开始爆发式增长。关于病毒的进化压力和宿主适应性的分析，让我对这些看似简单的病毒如何能在复杂的生态系统中持续生存，有了全新的认识。作者似乎有意避开了过多描述最新的基因编辑技术在该领域内的应用，而是更专注于病毒自身的“硬核”生物学特性。因此，它更像是一部奠基之作，为理解后来的复杂研究提供了坚实的地基。它要求读者投入大量精力去构建一个完整的知识框架，但回报是清晰、不易动摇的学科认知。

这本书给我的最大感觉是“系统性”和“不可替代性”。它不像那些专注于单一病毒（比如HCV或Polio）的单行本那样深入某一狭窄领域，而是以一个大家族的视角，对Picornaviruses 的生物学特性进行了全景式的扫描。我特别欣赏作者对不同病毒属之间共享的分子机制与各自特有的适应性策略的对比。例如，在讨论它们的非结构蛋白（NSPs）功能时，作者清晰地指出了不同属的病毒聚合酶在引发RNA变异性上的细微差别。这种横向比较，帮助我跳出了单一物种的研究视角，建立了一个更宏大的病毒学认知框架。对于正在筹备博士课题，需要选择一个合适的病毒模型进行深入研究的学生来说，这本书提供的“导航地图”是无价之宝，因为它全面评估了每个子家族的优缺点和研究潜力。它更像是一份详尽的“情报报告”，而非简单的知识点罗列，读完后感觉对整个Picornaviruses 领域已经了然于胸，可以自信地投入到任何细分领域的研究中了。

我以一个临床微生物学家的视角来审视这本书，我不得不说，《The Picornaviruses》在临床相关性和病理生理学讨论上的广度与深度，着实让人眼前一亮。市面上很多病毒学专著往往将重点过多地放在基础研究上，而忽略了这些病毒如何引发现实世界的疾病。这本书则不然，它花了大量篇幅来探讨小RNA病毒家族中各个主要成员（比如脊髓灰质炎病毒、柯萨奇病毒、肠道病毒71型等）的致病机制差异。特别是关于肠道病毒71型（EV71）引发的手足口病（HFMD）重症病例的神经系统并发症，书中的讨论非常深入，从病毒进入中枢神经系统的通路到其如何诱导炎症级联反应，都有详细的分子模型支撑。阅读这些内容时，我能清晰地感受到理论知识如何直接指导临床诊疗思路的构建。书中对疫苗研发历史的梳理也极其详尽，它不仅列举了成功的案例，还分析了那些失败的尝试背后的病毒学教训，这对于我们开发新型广谱抗病毒药物和疫苗提供了宝贵的历史借鉴。对于希望将基础研究成果转化为临床实践的研究人员和医生来说，这本书提供的视角是极其宝贵的。

这本《The Picornaviruses》简直是病毒学研究领域的一股清流，尤其对于那些像我一样，对核酸结构和复制机制着迷的“技术宅”来说，简直是一本武功秘籍。我花了整整一个周末沉浸其中，对那些微小的RNA病毒如何精准地劫持宿主细胞的“工厂”进行自我复制的过程，感到由衷的震撼。作者在阐述其生命周期时，那种庖丁解牛般的细腻，让人不得不佩服其深厚的积累。比如，他们对病毒蛋白酶如何精确地切割多聚前体蛋白的描述，简直是教科书级别的案例分析，每一个氨基酸残基的变化，如何影响最终的装配效率，都被描绘得淋漓尽致。我尤其喜欢其中关于翻译调控的那几章，Picornaviruses 绕过mRNA帽依赖性翻译的巧妙机制，简直是自然界中优化工程的典范。全书的图表和电镜照片质量极高，清晰地展示了不同病毒株在电子显微镜下的形态差异，这对于形态学分类的爱好者来说，是极其宝贵的直观资料。尽管内容专业性很强，但作者的叙事节奏把握得恰到好处，既有严谨的科学论证，又不乏对领域内重大突破的精彩回顾，读起来完全不会感到枯燥乏味，反而有一种逐步揭开科学谜团的快感。如果你想深入理解RNA病毒的分子生物学，这本书是绕不开的里程碑。