Statistical Monitoring of Clinical Trials

出版者:Springer Verlag

作者:Proschan, Michael A./ Lan, K. K. Gordan/ Wittes, Janet Turk

页数:282

出版时间:2006-8

价格:$ 157.07

装帧:HRD

isbn号码:9780387300597

The approach taken in this book is, to studies monitored over time, what the Central Limit Theorem is to studies with only one analysis. Just as the Central Limit Theorem shows that test statistics involving very different types of clinical trial outcomes are asymptotically normal, this book shows that the joint distribution of the test statistics at different analysis times is asymptotically multivariate normal with the correlation structure of Brownian motion ("the B-value") - irrespective of the test statistic. Thus, this book offers statisticians an accessible, incremental approach to understanding Brownian motion as related to clinical trials.