In Search of Memory

埃里克·坎德尔（Eric R.Kandel）1929年出生于奥地利的维也纳，1956年毕业于美国纽约大学，获医学博士学位。1983年至今任哥伦比亚大学生物化学与分子生物物理学系教授、霍华休斯医学研究中心高级研究员。2000年获诺贝尔生理学或医学奖。

出版者:W. W. Norton & Company

作者:Eric R. Kandel

页数:528

出版时间:2007-3-17

价格:USD 19.95

装帧:Paperback

isbn号码:9780393329377

图书标签:心理学神经科学Neuroscience科普传记思维英文原版记忆

From Publishers Weekly

When, as a medical student in the 1950s, Kandel said he wanted to locate the ego and id in the brain, his mentor told him he was overreaching, that the brain had to be studied "cell by cell." After his initial dismay, Kandel took on the challenge and in 2000 was awarded a Nobel Prize for his groundbreaking research showing how memory is encoded in the brain's neuronal circuits. Kandel's journey into the brain spans five decades, beginning in the era of early research into the role of electrical currents flowing through neurons and ending in the age of genetic engineering. It took him from early studies of reflexes in the lowly squid to the founding of a bioengineering firm whose work could some day develop treatments for Alzheimer's and on to a rudimentary understanding of the cellular mechanisms underlying mental illness. Kandel's life also took him on another journey: from Vienna, which his Jewish family fled after the Anschluss, to New York City and, decades later, on visits back to Vienna, where he boldly confronted Austria's unwillingness to look at its collusion in the Final Solution. For anyone considering a career in science, the early part of this intellectual autobiography presents a fascinating portrait of a scientist's formation: learning to trust his instincts on what research to pursue and how to pose a researchable question and formulate an experiment. Much of the science discussion is too dense for the average reader. But for anyone interested in the relationship between the mind and the brain, this is an important account of a creative and highly fruitful career. 50 b&w illus. (Mar.)

Copyright © Reed Business Information, a division of Reed Elsevier Inc. All rights reserved. --This text refers to the Hardcover edition.

From Scientific American

Kandel, who received the Nobel Prize in 2000, traces advances in understanding learning and memory. His own groundbreaking findings showed that learning produces changes in behavior by modifying the strength of connections between nerve cells. He conveys his immense grasp of the science beautifully, but it is his personal recollections that make the book especially compelling. He begins with his searing childhood memories of the German annexation of Austria and his family’s escape to the U.S. when he was nine. And he ends with a conference he organized in Vienna to examine the strange reluctance of Austria (unlike Germany) to acknowledge its role in the Holocaust. One comes away in awe of the scientific advances—and of a life well and fully lived.

Editors of Scientific American --This text refers to the Hardcover edition.

读后感

研究记忆的人经常会说我们对于分子机制了解的太多而对环路机制了解的太少。考虑到记忆中最重要的分子机制（例如cAMP通路）大部分都是由本书作者的实验室发现的，我们就可以理解他的贡献有多么重要。 此书基本上是作者对自己科学生涯的回顾，按照年代次序描述了他主要的科学发...  

这是我读过的最好的科普著作，等慢慢消化了再写个书评吧，先把几个勘误贴一下（整本书的翻译仍然是非常高质量的）。 P197倒数第二段。 译文：Watkins和Graham Collingridge发现在海马中谷氨酸充当两种受体：AMPA受体和NMDA受体，AMPA受体调节一般的突触传递并且在突触前神经元...  

用户评价

作为犹太人的个人心路历程+学术研究历程.科普水平很高.严谨+情怀. Kendel毕竟是哈佛历史系的本科, 讲起历史可不虚.不过要说"客观" 就不一定了.讲起脑科学当然是更不虚了.这东西着实有些意思.另,其主攻方向的转换多少于我是种鼓励.

:无

这书应该叫《科学家的自我修养》。同时也是神经科学很好的入门书（前提是你要有一些生物化学方面的知识）。

这种级别的科学家也是自己本学科最好的历史学家，看他讲这一个世纪神经科学的发展节骨眼上的悬念和突破，跟我同时在读的航海小说一样抓人。格物致知引人入胜和醍醐灌顶的亮点太多了：犹太少年成长史，记忆与学习的神经机制，精神分析与神经科学交叉点，科学方法论。头一回读书记了三十页读书笔记，以后要常复习。

这种级别的科学家也是自己本学科最好的历史学家，看他讲这一个世纪神经科学的发展节骨眼上的悬念和突破，跟我同时在读的航海小说一样抓人。格物致知引人入胜和醍醐灌顶的亮点太多了：犹太少年成长史，记忆与学习的神经机制，精神分析与神经科学交叉点，科学方法论。头一回读书记了三十页读书笔记，以后要常复习。