What You Need to Know About Hormones and Depression Research has shown a strong connection between estrogen levels and depression throughout a woman's lifetime. We now understand that abrupt hormonal changes can take a toll on women's moods and even cause serious depression. But the good news is that there is a lot women can do to moderate the effect of these changes. The Estrogen-Depression Connection explores this issue and offers practical advice and tips for managing mood changes throughout all the major stages of a woman's life-from puberty and menstruation to pregnancy and postpartum, and from perimenopause to menopause. It explains in easy-to-understand terms what women can do right now to help balance these estrogen fluctuations through diet and lifestyle changes, alternative therapies, and medication. Get the information you need: Learn how estrogen affects each stage of a woman's lifeCope with postpartum depression and menopauseFind the best medical and alternative treatments