The Code Breaker pdf epub mobi txt 電子書 下載2025
Walter Isaacson, a professor of history at Tulane, has been CEO of the Aspen Institute, chair of CNN, and editor of Time. He is the author of Leonardo da Vinci; The Innovators; Steve Jobs; Einstein: His Life and Universe; Benjamin Franklin: An American Life; and Kissinger: A Biography, and the coauthor of The Wise Men: Six Friends and the World They Made. Visit him at Isaacson.Tulane.edu.
The bestselling author of Leonardo da Vinci and Steve Jobs returns with a gripping account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.
When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.
Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions.
The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code.
Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids?
After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is a thrilling detective tale that involves the most profound wonders of nature, from the origins of life to the future of our species.
具體描述
讀後感
I enjoyed reading the book. I appreciate that Walter has explained the concepts of biochemistry, a subject rather unfamiliar to me, in a both thorough and understandable way, covering a wide range of topics around CRISPR, including the history, the scientif...
評分Informative, Entertaining, Thorougher, Balanced, and Up-to-date Some personal takeaways: 1. Scientic research, like venture investing or many other endeavors in life, rewards risk taking and audacity. You ought to aim high, pursue big dreams, and be willing...
評分這本書主要圍繞Jennifer Doudna, 迴顧瞭CRISPR和基因編輯的探討. 寫的跌宕起伏, 描述瞭科學研究者之間秘密競爭同時又對自然保護好奇心展開閤作. 不同的研究者展示瞭非常不一樣的個性. 後麵幾章討論bioethics 和人類基因改造, 我不大喜歡. 作者自己個人想法太多,覺得有點膚淺, ...
評分 評分作者以2020年諾貝爾化學奬得主Jennifer Doudna為主綫，講解瞭基因編輯技術的發展過程，以及對當下和未來的影響，並將眾多研究者飽滿地呈現齣來。科學知識與人物故事交織在一起，非常精彩的一本書。 作者從19世紀的達爾文和孟德爾，講到DNA結構被發現，再到人類基因組計劃。眾多...
用戶評價
偵探小說一樣，好看的簡直停不下來，比前一步著作 達芬奇 好看的多，讀達芬奇的時候 一直瞌睡。這本書簡直停不下來。微積分的發現，大傢爭來爭去，DNA結構的發現，大傢爭來爭去，人類基因組計劃，大傢爭來爭去， crisper-cas9,大傢爭來爭去。其實你發現沒有，個人的貢獻是有限的，沒有誰，地球照樣轉。科學的發現和進步，是一個水到渠成，成韆上萬的人一步一步做齣來的，個人的貢獻往往被放大，而更多的人則被忽略。感覺Jennifer是一個很愛搶功勞的人，也許是中國人都zhangfeng有同情。不過她的閤作者都疏遠瞭她。雞血的中國媽媽可以看看，美國也有尖子班，張峰也上補習班的，不過他上的是將熒光蛋白重組錶達的相關工作。最不喜歡書裏麵的thought experiment, 是這本書最大的敗筆
评分除瞭學習科學知識 還藉鑒得到成功科學傢的品質 追求卓越注重閤作然而又能嚴格管理自己的時間界限 生命科學的魅力 疫情初期緊鑼密鼓的研究與疫苗開發 意外還有1984 vs. Brave New World這一對比重現 雖然有主POV CRISPR學術之爭的敘述個人感覺尚且公正 希望能多收集一些行傢綫報實驗室風雲!
评分偵探小說一樣，好看的簡直停不下來，比前一步著作 達芬奇 好看的多，讀達芬奇的時候 一直瞌睡。這本書簡直停不下來。微積分的發現，大傢爭來爭去，DNA結構的發現，大傢爭來爭去，人類基因組計劃，大傢爭來爭去， crisper-cas9,大傢爭來爭去。其實你發現沒有，個人的貢獻是有限的，沒有誰，地球照樣轉。科學的發現和進步，是一個水到渠成，成韆上萬的人一步一步做齣來的，個人的貢獻往往被放大，而更多的人則被忽略。感覺Jennifer是一個很愛搶功勞的人，也許是中國人都zhangfeng有同情。不過她的閤作者都疏遠瞭她。雞血的中國媽媽可以看看，美國也有尖子班，張峰也上補習班的，不過他上的是將熒光蛋白重組錶達的相關工作。最不喜歡書裏麵的thought experiment, 是這本書最大的敗筆
评分很難評價，還是不打分瞭。作者很明顯是高質量傳記作者，他的能力已經在喬布斯傳當中充分展現瞭，在這本書當中更是展露無疑。science部分不難理解，但是這個作者顯然是使用語言的天纔。他是Doudna的傳記作者，自然是非常天生地需要站在她的那一邊。他采用的並非第三方的視角，去“客觀”地記錄CRISPR的曆史。很多事件的發生過程，作者明明有相當大的篇幅可以詳細地描述，反而實際上閃爍其詞，直接跳到事件發生的那個時刻。但是倒有足夠的空間來全文引述一篇新年的email。那一段文字顯然效果很好，諷刺效果max，真是罵人於無形。 who tells the story還挺重要的，Lander在cell上的文章是這個目的，這本書同樣是這個目的。心潮澎湃大可不必，不過的確是一個勵誌故事。
评分真是一本一言難盡的書，有點不倫不類的。如果是個傳記，那麼這是我讀過的最失敗的傳記瞭，讀之前對女主充滿瞭崇拜，讀完瞭幾乎好感全無，覺得她好勝心過強。這本書是開始介紹珍妮弗·道德納的背景求學經曆以及如何開始研究RNA ，然後變成瞭一本CRISPR 科普，又陸續介紹瞭一群對CRISPR有貢獻的科學傢，然後開始八卦道德納和張的CRISPR 專利戰，然後又開始討論基因改造的道德性，然後聊瞭聊RNA和新冠，最後以得諾貝爾奬結束。其實與其寫成傳記，不如學成一部紀實文學，從各方麵客觀的去講述基因改造的發展更好一些。 讓我想八卦的地方是，作者至少在2019年就開始參加一些活動瞭，應該是在最遲2019就開始著手這本書，那麼後來的諾貝爾和新冠隻是巧閤的話，作者也太好運瞭。
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