Matt Richtel is a Pulitzer Prize-winning New York Times journalist and bestselling writer of mysteries and thrillers. His books are fast-paced, character-centered stories in which things are not always as they seem. The backdrop for the books is the modern world. Technology is everywhere. Everything moves at lightning speed, from conspiracy, to love, business, and violence. Technology is our slave. Or has it become our dark master?
The books relate to Matt's journalism. He won the Pulitzer Prize in 2010 for a series of stories on distracted driving. The next year, he wrote an acclaimed series for the New York Times called "Your Brain On Computers" exploring how heavy technology use impacts our behavior and our brains.
Matt lives with his family in San Francisco. He writes from an office with a window that looks onto the former house of baseball legend Willie Mays. He -- Matt, not Willie -- is an avid tennis player, takes pride in making guacamole and coffee, and writes the occasional song.
发表于2025-03-29
An Elegant Defense 2025 pdf epub mobi 电子书
本书从四个美国人的故事出发,科普了人类免疫系统的知识,从抗体抗原,说到T细胞B细胞(我对免疫的了解基本到此为止),疫苗、器官移植,巨噬细胞、中性粒细胞、自然杀伤细胞,然后又说到白介素、干扰素、细胞因子,Toll受体、肠道微生物菌群,PD-1、皮质醇、单克隆抗体,抗生...
评分在这期间,杰森会带着他的姐夫保罗,和他一起开会和治疗。保罗是一个分子生物学博士,专利律师,一位具有科学背景的伟大倾听者。一天,他们坐在候诊室里,杰森开始说话:“你想知道癌症患者的感受吗?” “听听看。” “就像世界上所有人都住在美丽海滩上的塔希提村庄一样,我却住在独木...
评分It’s a moving story about immunity system and four patients. It’s the good combination of science and human being story. I like this story. I am amazed by the power of immune system which can automatically defeat the infections, but balance is also import...
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NATIONAL BESTSELLER
A grand tour of the human immune system and the secrets of health, by the Pulitzer Prize–winning New York Times journalist
“One of those rare nonfiction books that transcends the genre. ... Extraordinary.” —Douglas Preston
A terminal cancer patient rises from the grave. A medical marvel defies HIV. Two women with autoimmunity discover their own bodies have turned against them. Matt Richtel's An Elegant Defense uniquely entwines these intimate stories with science’s centuries-long quest to unlock the mysteries of sickness and health, and illuminates the immune system as never before.
The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. Its legion of microscopic foot soldiers—from T cells to “natural killers”—patrols our body, linked by a nearly instantaneous communications grid. It has been honed by evolution over millennia to face an almost infinite array of threats.
For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders.
Richtel effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. The foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and autoimmune treatments that are changing millions of lives. An Elegant Defense also captures in vivid detail how these powerful therapies, along with our behavior and environment, interact with the immune system, often for the good but always on a razor’s edge that can throw this remarkable system out of balance.
Drawing on his groundbreaking reporting for the New York Times and based on extensive new interviews with dozens of world-renowned scientists, Matt Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”
要不是自己得了不算很严重的自体免疫病,我今年也不会读好几本关于免疫系统的书。免疫系统是如此复杂和精确,只能说连现代医学对它的了解也依然很粗糙。过去我们总把免疫系统比喻成持续不断与病原体战斗的激进系统,其实是错的。过于活跃的免疫会伤害自身造成自体免疫病,免疫系统里也有自我刹车、调解与其他细菌和病毒和谐共处的机制。书里一些病人的例子,在吃一种药压抑/提升了免疫后又无意中带来一系列副作用,又需要另外的药在天平另一端进行调整,最后往往要十几种药一起吃。这个“平衡”实在太难把控。书最后总结的理念有点回归传统智慧的意思:讲究平衡、养生、holistic,吃饱睡好多运动,人人都知道,但不一定人人能做到。(我觉得中医的【养生理念】,注意我说的是理念,有一定道理。但如果生病了还是要靠现代医学,不要吃中药)
评分对免疫系统肃然起敬。
评分不是那种告诉你应该吃点啥,做点啥的书。吃真正的食物,永远保持运动/锻炼,这两点应该是不言而喻了。这本书用生动的例子介绍了人体神秘的免疫系统,以及免疫系统疾病。可以再读一遍。
评分第一本有声书
评分本科时学过免疫学,印象是各种难记的相互作用。很喜欢这本免疫科普书讲的免疫的发展历史,惊叹于教科书上那么多的知道其实很多只是近二三十年的发现。Impressive. It's all about balance and diversity.
An Elegant Defense 2025 pdf epub mobi 电子书